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UPDATE: Planned server room maintenance: Monday, August 26: The maintenance is moving along, but certain key ... http://t.co/uz8vRc1kHc— Folding@home (@foldingathome) August 26, 2013
A few key servers for Folding@Home project (the AS ones) are in maintenance for a few hours. Don't freak out, everything will be back online soon !
Source : Vijay's blog
EDIT : 27/08/2013 12:30pm UTC
Maintenance has been longer than expected due to network hiccups encountered after the servers were restarted. But today at about 2 am UTC, almost everything has been reactivated and things have been progressively doing better. Vijay Pande has officially announced it on Twitter after two intermediate messages :
New blog post: UPDATE 3: Planned server room maintenance: Monday, August 26 via Folding@home: The ... http://t.co/BV9WPp39Ez— Vijay Pande (@vijaypande) August 27, 2013
You should keep in mind that some type of WUs are still causing issues : for instance, I’m still unable to send or get work for my old nVidia GPUs (pre-Fermi).
Source: Vijay’s blog
EDIT : 27/08/2013 8:00pm UTC
As we already noticed in previous update, VSP07 server, which handles WUs mainly for core 11, is still broken. System administrator of University are still working hard to fix it and put it back on line.
UPDATE 4: Planned server room maintenance: Monday, August 26: Looks like everything is up, except for a singl... http://t.co/W8tXmHhm65— Folding@home (@foldingathome) August 27, 2013
Source : Vijay's blog
First, the influenza virus kills about 40 000 people in the USA every year and many more worldwide. These are mostly children under 2 and adults over 60. This is obviously something that concerns us because everyone hopes to have children in good health and to live beyond the age of 60 … Second, influenza has proven track records of causing global mass-mortality, such as in 1918. A similar virus today could easily kill much more than 60 million people and we’d like to be prepared. Finally, the influenza virus is an interesting model for understanding other viruses such as HIV and cancer-causing viruses such as HPV (Human papillomavirus), Heptatitis C, and Epstein-Barr virus. It might surprise you, but many cancers are associated to a virus and these form an important area of prevention.
Folding@home has done a lot of work on how influenza virus enters into cells to replicate. This is an important therapeutic target and it is critical to understand why some viruses like H5N1 (“bird flu” have not become efficiently transmissible between people. Some of the recent work on the topic focuses on the folding of the cell membrane which is necessary for viral entry. Professor Kasson’s team obtained interesting results and we will post a news article when they are published.
The researcher also presented a promising new software suite: Copernicus. Peter Kasson’s, Eric Lindhal’s and Vijay Pande’s teams published a paper back in 2011 on the topic and they have pursued developments. Copernicus essentially makes the back-end control of large-scale simulations much more transparent, so FAH researchers will be more easily able to integrate new methods. This software also works on supercomputers and cloud computing platforms which makes it easier to run simulations that complement the simulations run on Folding@Home. It also allows other researchers from outside FAH to gain access to the kind of simulations we run on FAH. All these changes are on server side, so the donors should not notice any difference in the client behaviour. But thanks to Copernicus, we should see new research areas appear.
Source: Vijay’s blog
However in practice, prescribing IL-2 to these patients often leads to severe heart problems. To find a better solution, researchers at Stanford University designed a variant of IL-2 that can stimulate this immune response without any side effects. However, they were unable to understand how this mechanism worked because the two proteins had almost identical structures!
Using Folding@Home, Doctor Bowman’s team showed that IL-2 is a relatively floppy protein while the one designed at Stanford is locked in a structure that is poised to stimulate an immune response.
Source: Vijay’s blog
A series of news will follow to summarize the main ideas that came out of this conference.
Here is a picture of most participants:
From top left to bottom right: TJ Lane (Stanford), Dr. Jason Wagoner (Stanford), Prof. Dr. Vincent Voelz (Temple), Dr. Sidney Elmer (Sandia National Lab), Dr. Fancesco Pontaggia (Brandeis), Dr. Lan Hua (UCSF), Bruce Borden (FoldingForum.org), Joseph Coffland (Cauldron Development), Dr. Diwakar Shukla (Stanford), Dr. Lee-Ping Wang (Stanford), Steven Kearnes (Stanford), Kyle Beauchamp (Stanford), Dr. Greg Bowman (UC Berkeley), Dr. Relly Brandman (UCSF), Robert McGibbon (Stanford), Prof. Dr. Yu-Shan Lin (Tuffs), Prof. Dr. Matt Jacobson (UCSF), Prof. Dr. Jesus Izaguirre (Notre Dame), Prof. Dr. Vijay Pande (Stanford), Prof. Dr. Michael Shirts (University of Virginia), Dr. John Chodera (UC Berkeley/QB3), Prof. Dr. Peter Kasson (University of Virginia), Prof. Dr. Xuhu Huang (Hong Kong).
Not pictured: Prof. Dr. Chris Snow.
Source: Vijay’s blog
So far, the researchers have shown that modern forcefields can accurately fold peptoids (results available on http://dx.doi.org/10.1002/bip.21575) and they are working with experimental collaborators on blind predictions of peptoid structures (new results will be published soon). Folding@Home would contribute to large-scale simulations of peptoid folding to better understand peptoid folding mechanisms and design principles.
Source: Vijay’s blog
The following main features have been announced by client developer, Joseph Coffland:
- Web control interface added
- Control buttons removed from FAHControl interface
- Simplified installation
For the time being we haven’t been able to test these new features, but we’ll take a closer look.
This is again a big change : the three frames which were part of the already simple interface are gone, replaced by a new home page completely dedicated to education with an animation oriented graphic style.
The website also emphasizes social networks (well yes, we’re not alone )
The text emphasizes the principles of protein folding, the opportunity to participate and introduces the network machines (us ) already in place.
To complete this release, a Youtube video has been posted to introduce its audience to the implication of misfolded proteins in a huge variety of diseases, and it explains how to participate in finding cures for them !
Let’s communicate !
Stanford has offered us great tools to promote the project more easily, the time has come to recruit. Your family, your friends, the forums and the online communities you’re involved in might be interested ! It would be a shame not to enjoy this beautiful dynamic !
Main source : Vijay’s blog
On Facebook of course we have the biggest community. This is a good way to promote the project among your family and friends by sharing our news when you think they might be interested.
On Twitter which is our oldest community, you’ll find some other accounts interesting to follow according to your needs. We’d like to say hello to donors from other distributed computing projects that are following us
On Google+ our latest and quickly growing community ! When sharing or adding some +1, you can help us reach the “featured” posts in regard to the user interests. This might be a good way to reach people in a targeted way.
Anyway, whether you’re a big social networks fan or not, thank you for your loyalty. Even when we’re not very active, we appreciate seeing you around on FAH-Addict !
The GeForce GTX Titan will be based on a GK110 chip, a development of the Kepler family, which is the first card on sale to use this component. The chip is supposed to be as powerful as 85% of a GTX 690 which is equipped with two high end Kepler chips !
The GK 110 chip is identical to the one embeded on the Tesla K20X GPGPU card. As a reminder, it is fitted with 15 SMX (2880 SP) with 14 activated (for 2688 SP). This chip is capable of delivering 3.95 GFLOPs on single precision calculations and 1.31 GFLOPs on double precision ones.
Here are some numbers, mostly as rumors, for the GeForce Titan GK100:
- Released on February 18th
- 2880 SP (15 SMX) with 2688 activated (14 SMX)
- 7.1 billion of transistors
- 502 mm² die
- GPU frequency : 732 MHz
- 6 GB GDDR5 on a 384 bits bus clocked at 1300 MHz
- 235W TDP
- Priced between $850 and $1000
In other words, a WU devourer ! Even if this kind of high end chip might be subject to early defects. nVidia is going to enforce strict design rules for this card on its partners, so no custom coolers!
The rumors about the availability date vary. The vast majority of the sources tends to point toward February 18th, though some of them mention the 25th …
Source : PC World (in French)
Of course, the cards in desktop cases are the main focus, but the laptop or high performance computing rack cards are more likely to be subject to these issues because they run in a much more confined environment. The good news is that most modern GPUs (Fermi or Kepler) are kept away from erroring by efficient thermal protections.
This experiment consolidates our usual advice : avoid folding on laptop GPUs, and make sure that your sensitive components are correctly cooled.
Source : Tom's Hardware France
One of the main goal of this laboratory is to use molecular simulations for computational design of folding and binding properties. This design requires folding for lots of different possible protein sequences, which is a natural task for the Folding@Home distributed computing platform. Vincent Voelz’ team works to consolidate Markov State Models of conformational dynamics to do efficient estimation of the effects of sequence perturbations. A good starting point to test these effects are to look at proteins for which many sequences have been characterized, to see if it is possible to predict sequence-dependent changes. Many of these sequence mutations are important in human diseases, so professor Voelz hopes to gain insight into these process as well.
High performance computing cluster at Temple University.
Source : Vijay’s blog