Reducing side effects of IL-2 protein used to treat cancers

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Today we are highlighting the work of Chris Garcia's laboratory at Stanford Medical School. The laboratory team had a great idea to re-engineer a very important protein used to treat cancers and Vijay Pande's laboratory got involved in the research by providing computer simulations that help to understand the mechanism by which the new protein worked. The results are exiting. You can access to the full article at this address:

http://medicalxpress.com/news/2012-03-scientists-boost-potency-side-effects.html

Summary
The utility of a naturally occurring protein given, sometimes to great effect, as a drug to treat advanced cancers is limited by the severe side effects it sometimes causes. But a Stanford University School of Medicine scientist has generated a mutant version of the protein whose modified shape renders it substantially more potent than the natural protein while reducing its toxicity.

Source: Vijay's blog