Protein folding and molecular recognition

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Here is message from Professor Xuhui Huang’s laboratory at Honk Kong University of Science and Technology, another research group that collaborates with Folding@Home project. Professor Huang and his laboratory have created many methodological applications to FAH (refer to this publication) as well as important research on the molecular nature of Huntington’s Disease. Here is an update from Professor Huang:

In the past couple of years, Folding@Home has greatly contributed to the team’s research on understanding the molecular recognition processes. Molecular recognition, such as enzymes that need to recognize their substrate and drugs that have to be designed to bind to specific receptors, is crucial to biology and medicine. Experimentally probing the chemical details of molecular recognition events is challenging, while computer simulations have the potential to provide a detailed picture of such events. With FAH donors’ help, the team is running large scale simulations on a group of Periplasmic Binding Proteins aiming to reveal the general relationships between protein structures, its intrinsic dynamics, and mechanism of recognition process.

Folding@Home projects involved in this experiment are in the 7700-7712 range. Professor Huang’s team greatly appreciates the help of all the FAH donors, the beta testers and the rest of the FAH team to make their research on molecular recognition possible.

Source: Vijay’s blog